Stability of T-cell repertoires in transplanted patients. (A) TRBV gene use, normalized (heat map indicates z-score) and clustered by row (sample). Each clone is only counted once per sample. TRBV genes that account for <1% of total clones are excluded. Each row is labeled with the sample name and time point and the clone number is given in parentheses. (B) Venn diagrams showing clone numbers that are found at each time point and those that overlap between 2 time points (based on the same samples and time points that are shown in panel A). (C) Ranks of the T-cell clones that overlap between the 2 time points. Numbers to the left indicate the subjects. Columns indicate the time of the sample, with time point 1 (t1) being the earlier time point and t2 the later time point (same samples and time points as in panel A. Numbers in the cells indicate the clone ranks, which are also shown in the heat map. A rank of 1 indicates the clone with the highest sequence copy number fraction in the sample. Only clones with a combined rank of <100 (summed ranks of t1 + t2) are shown.