Schema of 4 algorithms giving rise to 3 different MK populations. Immune megakaryocytes (iMKs), niche-supporting megakaryocytes (NS-MKs), and platelet generating megakaryocytes (PG-MKs). The third algorithm includes the possibility of generation of iMKs from dendritic cell progenitors (DCPs), from monocytic progenitors (MoPs), or from immune MK-progenitors (iMK-Ps). The fourth algorithm summarizes the generation of iMKs and PG-MKs directly from MK-primed hematopoietic stem cell (HSC-MK) during inflammation.