Wnt/β-catenin signaling controls erythropoiesis. Schematic overview reflecting the control of Wnt/β-catenin signaling on erythropoiesis. As reported during primitive hematopoiesis by stimulating primitive erythropoiesis in the yolk sac and by promoting erythroid progenitor formation during definitive hematopoiesis in the AGM region (A). Wnt/β-catenin also stimulates erythroid progenitor formation in the spleen of mice to promote stress erythropoiesis during anemia (B). Additionally, erythroid progenitor formation is supported by Wnt/β-catenin signaling by directing hematopoietic progenitor differentiation toward the erythroid lineage (C) and during BM injury to support recovery of erythropoiesis (D). Constitutive activation of Wnt/β-catenin in the hematopoietic lineage in mice however causes dyserythropoiesis (E), which correlates with MDS development and progression into AML (F).