Treatment with P-G6 reduces venous thrombus formation. A nonocclusive thrombus was induced be electrolytic injury of the inferior vena cava, and vessel thrombus weight was measured 48 hours after injury to determine treatment efficacy. (A) Prophylactic administration of P-G6 (8 µmol/kg IV) and low molecular weight heparin (LMWH; 6 mg/kg, subcutaneously) resulted in a significant reduction in thrombus weight compared with mice administered saline vehicle (8 mice per group). (B) Representative images of excised infrarenal vena cava 48 hours after electrolytic injury. (C-F) Neutrophil and macrophage infiltration within the vein wall 48 hours after thrombus induction. Quantification of Ly6G⁺ neutrophils (C,E) and CD68⁺ macrophages (D,F) reveals significantly less wall inflammation compared with mice administered saline vehicle. Arrows indicate positive immunostaining scale bar displayed in saline group applies to all images. Data are mean ± SEM. ***P < .001, ANOVA with Tukey’s multiple-comparison test. L, lumen.