Increased free nucleosomes in serum samples from MPN patients and healthy donors. Free nucleosomes were quantified by ELISA in serum samples from (A) MPN patients and healthy donors and (B) healthy donors and MPN patients (n = 83) according to MPN subtype. Data are presented as x-fold referring to positive control. Boxplots show the 25% and 75% quartiles and the median; overlayed dot plots indicate individual measurements. MF, myelofibrosis.