Induced NETosis rates in neutrophils from patients with MPN and healthy donors. (A) NETosis rates in MPN subgroups compared with those in healthy donors quantified by ELISA, and (B) driver gene mutations. Data are presented as x-fold of vehicle controls. Boxplots show the 25% and 75% quartiles and the median; overlayed dot plots indicate individual measurements. P values were Benjamin-Hochberg (BH) corrected. Correlation of NETosis rates with JAK2 allelic burden according to MPN subgroup for (C) PV, (D) ET, and (E) MF. Dots represent single measurements, allelic load is shown as a percentage, and NETosis is shown as x-fold of vehicle controls.