Survival of AML patients in relation to the presence of SF mutations. (A) Kaplan-Meier analyses of EFS (left) and OS (right) in the total AML cohort in relation to SFmut4. Multivariable Cox regression analysis of EFS in relation to SFmut4 with complete (C) and modified (D) ELN 2017 classification. In the modified ELN 2017 classification RUNX1 and ASXL1 mutations were excluded, so that patients carrying RUNX1 or ASXL1 mutations were reclassified based on the presence of the rest of aberrations in this classification system. The type of stem cell transplantation violated the proportional hazard assumption; therefore, it was used as strata variable in all of the multivariable Cox regression models (for variables used in the model as strata, the statistics were not calculated and do not appear in the results). Kaplan-Meier curves for EFS (D) and OS (E) in relation to the mutation status of SF3B1 within the favorable- or intermediate-risk groups, as defined by the ELN 2017 classification. HR, hazard ratio; Ref, reference; WT, wild-type; 95% CI, 95% confidence interval.