cIAP1, cIAP2, and XIAP expression during LCL161 treatment for MF. IAP protein expression. Samples were collected on C1D1, C2D1, and C3D1. Protein levels of cIAP1, cIAP2, and XIAP were determined by Western blot, quantified using the Odyssey software, and expressed as levels related to those in baseline (C1D1) or to those in OCI-AML3 cells (as a control). (A) IAP levels in samples from responders (≥ 2 years). (B) IAP levels in blood samples from responding, then relapsed patient samples. (C) IAP levels in samples from nonresponders. (D) IAP levels in baseline C1D1 samples. Differences between groups were assessed with the Student t test. *P < 0.05; **P < 0.01; ***P < 0.001; *****P < 0.0001.