Prolonged survival in leukemic mice with elevated TSAT. (A) Mice transplanted with AML were treated with dextran (Dx) or iron dextran (FeDx). On a separate cohort, WT or Hfe^−/− mice were transplanted with MLL-AF9⁺ AML. (B) FeDx-treated mice and Hfe^−/−mice had increased TSAT. Kaplan-Meier curve showing improved survival of leukemic FeDx (C) and Hfe^−/− mice (D). n = 5-8 mice per group.