Increased TSAT at diagnosis is associated with increased OS. Kaplan-Meier curves showing no association between overall survival (OS) (A) and ferritin levels (cutoff: median of 821 ng/mL), but OS advantage (B) for patients with AML with elevated TSAT (cutoff: median of 51.5%). n = 84 patients. (C) Kaplan-Meier curve showing improved OS of patients with AML with lower heavy (FTH1) to light ferritin chain (FTL) expression ratio, a surrogate for increased LIP. Data from TCGA.