Iron metabolism in human AML at diagnosis. (A) Ferritin, serum iron, transferrin levels, and transferrin saturation (TSAT) were analyzed in a cohort of 84 AML patients (supplemental Table 1) at diagnosis. (B) An analogous evaluation was made in a group of 29 patients with rheumatological disorders (supplemental Table 2) and anemia of inflammation. (C) Summary of the key differences in iron profile observed in AML and in inflammation. (D) Comparison of the same parameters and in the same population described in panel A, according to the transfusional status (nontransfused [NT]; transfused [T]). (E) Iron-related parameters were analyzed in plasma collected from 11 patients with AML at diagnosis and from 12 patients with other conditions, mostly lymphoproliferative disorders (supplemental Table 3).