Graphical representation of the characteristics, therapy and outcome of the patients with progression of thrombosis or with recurrent thromboses. In patient #1, who discontinued the TRA at the time of first thrombosis, the second event occurred 30 days after TRA discontinuation. In patients #2 and #3, progression of thrombosis occurred after 2 and 29 days, respectively. Patient #3 died from renal cell carcinoma. Response: platelet count ≥30 × 10⁹/L and at least a twofold increase over the baseline count. AT, arterial thrombosis; VT, venous thrombosis; F, female; M, male; PT, patient.