Activation of fibrinolysis and cleavage of HK in plasma from human patients with ALF. (A) Plasma ALT activity in normal individuals (control) and patients with ALF. (B) Circulating concentration of PAP complexes. (C) tPA-mediated clot lysis time. Longer times indicate reduced fibrinolytic capacity. (D) Plasma concentration of intact HK. (E) Plasma concentration of cleaved HK. N = 8 normal controls, 67 with ALF. Bars represent the sample mean. *P < .05, **P < .01, ****P < .0001.