Gene mutational maps of candidate driver genes with c-AID signatures involved in CLL progression. Graphic representation of 11 selected mutated genes with c-AID signatures separated in oncogenes (A), tumor supressors (B), and genome chromatin/histones (C) categories. Red gene names highlight previously described tumor drivers in human cancers. Black asterisks refer to mutations detected in the whole-leukemic clone; red asterisks indicate mutations found in the Ki67⁺ fraction. Key domains where AID mutations are detected and the corresponding base-pair number for each gene map are shown. Specifically, in the case of histones, red characters indicate substitutions in H1.3 (Leu₈₃→Phe and Ser₉₀→Asp) and in H1.4 (Leu₈₂→Phe) located at conserved DNA-binding domains. Leu₈₂→Phe substitution was found in 3 different mice of both DT-AID strains. For H1.4, the Ala₁₁₁→Thr and Ala₁₁₂→Thr changes are placed within the AKP helix motif of domain H15, which is essential for this histone family’s functional integrity. For H2A, the Glu₆₅→Asp mutation directly affects the DNA-binding site. Blue characters identify individual TCL1/Igκ-AID mice carrying c-AID mutations; red characters identify TCL1/act-AID mice.