Mutational frequencies affecting genes involved in pathways of interest in GCB DLBCL, nm-PMBLsig⁺ tumors, and bf-PMBL. (A) JAK-STAT mutations are frequent in both nm-PMBLsig⁺ tumors and bf-PMBL. Frequencies of mutations affecting genes involved in JAK-STAT signaling are shown for GCB DLBCL, nm-PMBLsig⁺ tumors, and bf-PMBL. (B) NF-κB signaling mutations are frequent in both nm-PMBLsig⁺ tumors and bf-PMBL. Frequencies of mutations affecting genes involved in NF-κB signaling are shown for GCB DLBCL, nm-PMBLsig⁺ tumors, and PMBL. (C) Immune response mutations are common in all 3 subtypes. Frequencies of mutations affecting genes involved in immune response are shown for GCB DLBCL, nm-PMBLsig⁺ tumors, and bf-PMBL.