Time to first CLL therapy in MBL and Rai 0 CLL. (A) Time to first treatment by CLL-IPI risk score in the overall cohort. (B) Time to first treatment in monoclonal B-cell lymphocytosis, according to the CLL-IPI risk score, and (C) time to first treatment in Rai 0 chronic lymphocytic leukemia, according to the CLL-IPI risk score. Note: Individuals with MBL who had very high-risk CLL-IPI score (n = 4) did not need therapy with current follow-up and hence panel B does not show any events for that group.