RPS15 mutations mostly affect translation rather than transcription. (A) Cluster dendrogram based on unsupervised agglomerative hierarchical clustering analysis of the 4000 most variable genes (based on standard deviation). (B) Scatterplot indicating differentially expressed genes (log2FC≥|2|; P < .05) at mRNA and RPF level in RPS15^mut vs RPS15^wt CLL cases. The x-axis represents the log2FC of mRNAs, while the y-axis represents the log2FC of RPFs. The color code (green to red) indicates the statistical significance of the observed differences. Squares indicate genes that show differential expression at mRNA level only, circles indicate the genes that show differential expression at RPF level only, and stars indicate the genes that show differential expression at mRNA and RPF level.