Differential chromatin accessibility in sensitive and resistant cell lines. (A) Heat map of all differentially accessible peaks. (B) Principle component analysis of ex vivo differentiated memory B (MB; blue) and plasma cells (PC; red) compared with myeloma cells resistant (orange) and sensitive (green) to venetoclax. The percentage of variation explained by each principle component is shown in parenthesis on the axes labels, and the 90% confidence interval of the standard deviation for each group is denoted by an ellipse. (C) Odds ratio of overlap of venetoclax-sensitive (green) and venetoclax-resistant (orange) myeloma cell differentially accessible regions (DAR) with those between MB and PC. Error bars denote the 95% confidence interval calculated by using a two-sided Fisher’s exact test. (D) Average chromatin accessibility of MB and PC at regions more accessible in venetoclax-resistant (left) and venetoclax-sensitive (right) cells. P values were calculated by using a two-sided Student t test. RPM, reads per million mapped reads; RPPM, reads per peak per million.