Partially reactivated B-cell program in myeloma cells as proposed model for venetoclax sensitivity. Gupta et al demonstrated that myeloma cells sensitive to venetoclax are enriched for B-cell genes, including CD20 and CD79A. This partially reactivated B-cell program is related to a B cell–like chromatin accessibility pattern favoring an increased binding of transcription factor involved in B-cell development such as BATF. Whereas most patients with B cell–like phenotype belong to the t(11;14) subgroup, this aberrant B-cell phenotype could be identified in patients from other molecular subgroups (ie, hyperdiploid and musculoaponeurotic fibrosarcoma [MAF]).