Characterization of the phenotype of BM-MSC treated by EVs purified from FL BM plasma. (A) Representative image of transmission electron microscopy of EVs harvested by ultracentrifugation of HD BM plasma (upper) and FL BM plasma (bottom). (B) Size analyze by TRPS of EVs harvested from HD BM plasma (upper, n = 4) or FL BM plasma (bottom, n = 4). Data are represented as the mean ± SD. (C) qPCR of BM-MSCs treated by 15 µL EVs freshly enriched from BM plasma of HD (n = 6) and FL patients (n = 13). Results expressed as fold change of untreated BM-MSCs. *P < .05; ** P < .01. (D) Luminex assay on BM plasma from HD BM (n = 10) and FL BM (n = 20). P < .05, **P < .01, ***P < .001.