Distributions of clinical characteristics across the 4 subgroups defined by the presence and site of bulky disease. (A) Age. (B) Pathology subtype. (C) Bone marrow involvement. Group 1, no bulky disease (maximum tumor diameter <5 cm). Group 2, bulky disease (≥5 cm) involving the mediastinum. Group 3, bulky disease (≥5 cm) outside of the mediastinum. Group 4, bulky disease (≥5 cm) both within and outside of the mediastinum. LD, lymphocyte deleted; LR, lymphocyte rich.