Gata2b loss results in differential chromosome accessibility in lineage-defining loci. (A) Example of scATAC-seq tracks of cell identity defining genes for immature hematopoietic cells. (B) Example of scATAC-seq tracks of cell identity defining genes for mature hematopoietic cells. Genescore denotes chromatin accessibility of the gene body and 2 kb above transcriptional start site. Log₂ fold-change (FC) of genescores in KO vs WT samples shown. (C) Examples of scATAC-seq peaks for select genes in WT and gata2b^ko samples. 10× Genomics scATAC-seq normalized tracks shown; GATA2 motif tracks show presence of GATAAG sequence.