Figure 3.
Increased lymphoid epigenetic priming in gata2bkozebrafish by scATAC-seq. (A) Differential TF motif score analysis between WT and gata2bko (KO) zebrafish within HPC population. (B) Feature plots of WT and gata2bko samples for SPI1 motif score within individual cells in the HPC population. (C) Violin plot of SPI1 TF motif score in WT and gata2bko HPCs. *P = 1.68 × 10−5, 2-tailed Student t test. (D) Differential TF motif score analysis between WT and gata2bko samples within B lineage (LP, LymphProg, B-cell progenitor and precursors, and mature B cells). (E) Feature plots of WT and gata2bko samples for IRF4 motif score within individual cells in lymphoid lineage. (F) Violin plot of IRF4 TF motif score in WT and gata2bko B-cell precursors. *P = 8.37 × 10−6, 2-tailed Student t test.

Increased lymphoid epigenetic priming in gata2bkozebrafish by scATAC-seq. (A) Differential TF motif score analysis between WT and gata2bko (KO) zebrafish within HPC population. (B) Feature plots of WT and gata2bko samples for SPI1 motif score within individual cells in the HPC population. (C) Violin plot of SPI1 TF motif score in WT and gata2bko HPCs. *P = 1.68 × 10−5, 2-tailed Student t test. (D) Differential TF motif score analysis between WT and gata2bko samples within B lineage (LP, LymphProg, B-cell progenitor and precursors, and mature B cells). (E) Feature plots of WT and gata2bko samples for IRF4 motif score within individual cells in lymphoid lineage. (F) Violin plot of IRF4 TF motif score in WT and gata2bko B-cell precursors. *P = 8.37 × 10−6, 2-tailed Student t test.

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