Individual disease courses in 87 patients with hTTP (46 male patients and 41 female patients) after enrollment until last visit up to December 2019. (A) Follow-up (in years) is given on the x-axis; individual patients are listed on the y-axis. Brackets (to the left of the patients’ numbers) link patients with affected family members participating in the registry. Patients are sorted according to sex and use of prophylaxis. (B) Extract of the whole cohort, depicting patients aged <18 years at enrollment (n = 25), sorted according to age, starting with the youngest child. Patients are divided (from uppermost to lowest on the ordinate) in groups of 0 to <6 years of age (n = 11), 6 to <12 years of age (n = 6), and 12 to <18 years of age (n = 8).