Patients with sickle cell disease–associated kidney failure exhibited similarly lower mortality with kidney transplantation compared to those with other etiologies. Nonetheless, patients with sickle cell disease are less likely to receive transplantation, even after waitlist registration. Visual abstract by Michelle Lim, MBChB, MRCP; adapted with permission from Sunjae Bae et al. CJASN 2021;16:407-414.