Genomic and immunogenetic landscapes of IGLV3-21^R110 CLL. (A) Presence of specific driver alterations in cases with and without IGLV3-21^R110. Driver alterations found in ≥10 cases are shown. Q values by Fisher’s exact test with Benjamini-Hochberg correction. (B) Oncoprint representation (variables in rows, cases in columns) showing main clinical variables (diagnosis and Binet stage), IGHV mutational status and subset 2, features associated with characterization of IGLV3-21, and CLL driver alterations. Bar plot represents total number of driver alterations for each case (bottom). Based on enrichment of IGLV3-21^R110 in i-CLL subtype, all i-CLL cases are depicted for comparison purposes. In contrast, only m-CLL and n-CLL expressing IGLV3-21 are illustrated. Percentages represent fraction of cases carrying each specific driver alteration among IGLV3-21^R110 i-CLL cases (left) and i-CLLs lacking IGLV3-21^R110 (right). Bar plot represents Q values by Fisher’s exact test with Benjamini-Hochberg correction (right). Q < 0.1, ***Q < 0.0001. CN, copy number; NA, not available.