Prevalence of IGLV3-21 among CLL subtypes and presence of IGLV3-21^R110 mutations. (A) Bar plot showing light-chain expression among CLL subtypes based on IGHV mutational status (left) and epigenetic subtype (right) for C1-CLL cases. (B) IGLV3-21 allele and presence or absence of R110 mutation among cases expressing the IGLV3-21 gene. (C-D) Same as panels A and B, but for C2-CLL cases (validation cohort). NA, not available.