Figure 1.
![The structure of the ET3i fVIII/anti–C1 domain 2A9 Fab fragment. (A) Ribbon diagram representation of ET3i in complex with the 2A9 anti–C1 domain Fab antibody fragment (Protein Data Bank identifier [PDBID#] 7K66) (pink, porcine A1 domain; dark magenta, porcine A3 domain; dark teal, human A2, C1, and C2 domains; orange, 2A9 Fab light chain [LC]; green, 2A9 Fab heavy chain [HC]). (B) Direct molecular contacts between the 2A9 antibody and the C1 domain 2065-2070 loop. (C) Direct molecular contacts between the 2A9 antibody and the C1 domain 2050-2056 loop. (D) Surface contacts between the 2A9 antibody and the A3 domain 1743-1748 loop and the second N-acetylglucosamine (NAG) residue N-linked to Asn1810.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/137/21/10.1182_blood.2020008940/1/bloodbld2020008940f1.png?Expires=1727799766&Signature=FiBROPgeQ5KOuK3rEUXl4Wmq8wsL8pAfQUpdaQ9vSVjeAkDUIyMGE4jeYBRNvbjReybki5AqqE2iQubF-CDpDRD5stq5odsPYKZ1Qu1HenAXlWpDmYTnTZsGBO2UiAIFv-0RKopGW8F6Ns6lQ3jz9djiLaKVl53oW2Xmn1G7EGDFqYA~24W0N4dGDOebeZWeFAZhgI-Rvld-4zIeSaS1XZPGVryKr01UMZ~aK6puUmFOcSHBXy4DrFqocZIkp97~1m4D2MW7iaI0vmy7zU3kn0Zb9qFAJopzUd5wQ0lWsjOrchyoRwDh-x47bK4PyTvKMwIbx0kizjJKWe4h1mm6Zw__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
The structure of the ET3i fVIII/anti–C1 domain 2A9 Fab fragment. (A) Ribbon diagram representation of ET3i in complex with the 2A9 anti–C1 domain Fab antibody fragment (Protein Data Bank identifier [PDBID#] 7K66) (pink, porcine A1 domain; dark magenta, porcine A3 domain; dark teal, human A2, C1, and C2 domains; orange, 2A9 Fab light chain [LC]; green, 2A9 Fab heavy chain [HC]). (B) Direct molecular contacts between the 2A9 antibody and the C1 domain 2065-2070 loop. (C) Direct molecular contacts between the 2A9 antibody and the C1 domain 2050-2056 loop. (D) Surface contacts between the 2A9 antibody and the A3 domain 1743-1748 loop and the second N-acetylglucosamine (NAG) residue N-linked to Asn1810.