Figure 4.
![Transitions in the values of CCFs of somatic mutations during transformation from CLL to RS in each CHOP-O patient. We observe clonal expansions (ie, cancer cell fractions [CCF] values increase from PB-CLL to tissue-RS), clonal contractions (ie, CCF values decrease from PB-CLL to tissue-RS) or clonal stability (ie, CCF values remain roughly the same between PB-CLL and tissue-RS). Each gray line indicates the transition of a single SNV/InDel from PB-CLL to tissue-RS. If a variant is absent in 1 phase, no transition line is shown.](https://ash.silverchair-cdn.com/ash/content_public/journal/blood/137/20/10.1182_blood.2020005650/1/bloodbld2020005650f4.png?Expires=1720293479&Signature=3HpbShb9jRAVWoblY4N81E9z4MEVdTsXzCnJpQdm588biewM~xkrGSQwwYCYko-2yFc9pBIrqOqQX~3cXJtCUZptvZ4NYBifbJVfoL1zdMor6lW3gNiRE9dgTngHwWUwSfrETujxpgUrWnS1UL5cEJfASiBN4zEkWJG1EfcN-0eNqD4YDtkOcafM7QcxLEjFtKErn1i9UDmby-6OUND6piKr~blOM3cAR-VNa5i5flPhCzZjeydIMbcXDC2E3gNHMQoVPy6mMfVbfBJF~TZ1D13lMuiSH0vFcCg8qIiECmrkZ5-hiFjATGJPotqJZGiNvZG9hGuBH~Ab3sHsEL6QZQ__&Key-Pair-Id=APKAIE5G5CRDK6RD3PGA)
Transitions in the values of CCFs of somatic mutations during transformation from CLL to RS in each CHOP-O patient. We observe clonal expansions (ie, cancer cell fractions [CCF] values increase from PB-CLL to tissue-RS), clonal contractions (ie, CCF values decrease from PB-CLL to tissue-RS) or clonal stability (ie, CCF values remain roughly the same between PB-CLL and tissue-RS). Each gray line indicates the transition of a single SNV/InDel from PB-CLL to tissue-RS. If a variant is absent in 1 phase, no transition line is shown.