Prognostic significance of different statuses of NGS MRD at the first and second time points. The Kaplan-Meier curves stratified by the NGS MRD status for CIR (A), RFS (B), and OS (C). The MRD^2nd− patients, either MRD^1st− or MRD^1st+, had a better outcome than MRD^2nd+ patients. The MRD^1st−MRD^2nd+ and MRD^1st+MRD^2nd+ patients had a similar dismal prognosis, whereas MRD^1st+MRD^2nd− patients had a good prognosis similar to that of MRD^1st−MRD^2nd− patients.