Prognostic impact of NGS MRD. (A-C) The CIR, RFS, and OS of patients stratified by the MRD status, detected at either the first or second time point. Patients with detectable MRD had significantly poorer outcomes than those without MRD. (D-I) The CIR, RFS, and OS of patients stratified by the MRD status at the first (D,F,H) and second time points (E,G,I). The difference in outcome remained significant at both time points. NE, not estimated.