Comparative outcomes of MPN-BP vs de novo AML. (A) Adjusted probability of OS of MPN-BP vs de novo AML in remission. The OS of MPN-BP patients in remission was significantly inferior to de novo AML patients in remission (HR, 1.40 [95% CI, 1.12-1.76]; P = .003). (B) Adjusted probability of OS of MPN-BP vs de novo AML with active leukemia. The OS was similar in MPN-BP patients with active leukemia compared with de novo AML patients with active leukemia (HR, 0.93 [95% CI, 0.72-1.20]; P = .59). (C) Adjusted cumulative incidence of relapse of MPN-BP vs de novo AML in remission. The relapse rate in MPN-BP patients in remission was significantly higher compared with de novo AML in remission (HR, 2.18 [95% CI, 1.69-2.8]; P < .0001). (D) Adjusted cumulative incidence of relapse of MPN-BP vs de novo AML with active leukemia. No difference in relapse rate was seen in MPN-BP patients with active leukemia vs de novo AML patients with active leukemia (HR, 1.16 [95% CI, 0.88-1.54]; P = .30).