Figure 4.
Associations between ferritin, tumor IFN, and M-MDSCs. Baseline tumor biopsy specimens collected within 1 month before axi-cel infusion and analyzed for gene expression by NanoString IO360 (770 genes) with available ferritin data (n = 36). Comparison between patients with a high baseline ferritin value (>1000 ng/mL; n = 8) and a lower value (<999 ng/mL; n = 28). (A-E) Shown are the macrophage score (A), representative macrophage markers CD68 (B) and CD163 (C), and IFN target genes IFIT3 (D) and OAS1 (E). (F) Comparison between patients with a high (>250 cells per mL; n = 13) or low (<250 cells per mL; n = 13) baseline M-MDSC level for ferritin on day −6. P values by nonparametric Mann-Whitney t tests. *P < .05; **P < .01. mRNA, messenger RNA.

Associations between ferritin, tumor IFN, and M-MDSCs. Baseline tumor biopsy specimens collected within 1 month before axi-cel infusion and analyzed for gene expression by NanoString IO360 (770 genes) with available ferritin data (n = 36). Comparison between patients with a high baseline ferritin value (>1000 ng/mL; n = 8) and a lower value (<999 ng/mL; n = 28). (A-E) Shown are the macrophage score (A), representative macrophage markers CD68 (B) and CD163 (C), and IFN target genes IFIT3 (D) and OAS1 (E). (F) Comparison between patients with a high (>250 cells per mL; n = 13) or low (<250 cells per mL; n = 13) baseline M-MDSC level for ferritin on day −6. P values by nonparametric Mann-Whitney t tests. *P < .05; **P < .01. mRNA, messenger RNA.

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