Diseases significantly related to (A) overexpressed and (B) underexpressed isolated PE-related proteins in literature. To generate these Chord diagrams, the same protein selection as was incorporated in the STRING network analysis was used. Connections with specific diseases were made by algorithmically searching PubMed for each protein, and testing which diseases were overrepresented among the search results, determined using a 1-sided Fisher’s exact test. The areas of the connections in these figures are proportional to the –log10-transformed P values derived from these tests. Cancer-related results were filtered because individuals with active cancer are excluded from this analysis.