OS and PFS according to molecular profile. PFS (A), OS (B), PFS according to CXCR4 mutational status and the type of CXCR4 mutation (frameshift vs non-sense) (C), and PFS according to TP53 mutational status (D). (C) Red line, absence of CXCR4 mutation [CXCR4(WT)] (left panel), green line, CXCR4 mutation non-sense [CXCR4(NS)]; blue line, CXCR4 mutation frameshift [CXCR4(FS)]. (D) Red line, absence of TP53 mutation (WT); blue line, TP53 mutation (MUT).