Schematic overview of the role of miR-29–TRAF4 axis in regulation of CD40-induced NF-κB signaling. MYC upregulation by BCR signaling activation downregulates miR-29 expression in the immune niches. This allows for higher levels of its direct target TRAF4, which acts as a positive regulator of CD40 signaling. BCR signaling inhibitors (ibrutinib/idelalisib) inhibit the BCR-induced MYC levels leading to higher miR-29 levels and repression of TRAF4. miR-29 also targets antiapoptotic proteins MCL1 and TCL1.