CRISPR-Cas9 screens in bortezomib-treated MM cell lines. (A) sgRNA waterfallplot for OPM2 cells treated continuously with 3 nM bortezomib. (B) sgRNA waterfallplot for MM1S cells treated continuously with 1 nM bortezomib or intermittent treatment with 100 nM for 4 hours. (C) Significant his per cell line ranked by sgRNA z-score