Heatmap of genes scoring significantly in CRISPR-Cas9 screens. SgRNAs targeting the listed genes conferred resistance (red) or sensitivity (blue) to ≥1 of the tested drugs (Bor, bortezomib; Dex, dexamethasone; Len, lenalidomide; Mel, melphalan) in ≥1 cell line. A cross indicates that the cell line carries a mutation in the respective gene (according to the Cancer Cell Line Encyclopedia database³³ ).