Inborn and somatic errors of immunity driven by nucleic acid sensors. (A) Clinical phenotypes associated with loss-of-function variants underlying autosomal dominant (TLR3) or autosomal recessive deficiencies (TLR3, UNC93B1, MYD88, IRAK-4, and MDA5). (B) Clinical phenotypes associated with gain-of-function variants underlying autosomal dominant disorders (RIG-I, MDA-5, STING, and TLR8).