Frequency of cooccurring or mutually exclusive mutated genes in SF3B1-mutated or unmutated MDS in the IWG data set. (A) Most frequent cooccurring or mutually exclusive mutated genes in SF3B1-mutant MDS in the IWG data set. Red and blue bars represent relative frequencies (percentage) of mutated genes in SF3B1-mutated and SF3B1-wild-type MDS, respectively. Red or blue gene labels indicate significantly higher frequencies of the comutated gene in SF3B1-mutated or SF3B1-wild-type MDS, respectively (P values ranging from .019 to <.001). (B) Most frequent cooccurring or mutually exclusive mutated genes in SF3B1-wild-type vs SF3B1-mutant MDS-RS in the IWG data set. Blue and red bars represent relative frequencies (percentage) of mutated genes in SF3B1-wild-type and SF3B1-mutant MDS-RS, respectively. Blue or red gene labels indicate significantly higher frequencies of the comutated gene in SF3B1-wild-type or SF3B1-mutant MDS-RS, respectively (P values ranging from .047 to .002).