Effect of current WHO classification criteria on OS of patients with SF3B1-mutated MDS. (A) OS of patients with SF3B1-mutated MDS according to the presence of single-lineage (blue curve, n = 267) or multilineage (red curve, n = 171) dysplasia (P = .4). (B) OS of patients with SF3B1-mutated MDS according to bone marrow blasts <5% (blue curve, n = 341) or ≥5% (red curve, n = 85) (P < .001).