Association of G9a/GLP targeting and epigenetic repressive marks. (A) Molecular signature of G9a/GLPi target genes in 3 HMCLs (OPM-2, XG20, and XG24) was investigated using the GSEA database (all curated gene sets), and relevant pathways are presented (FDR q value ≤ 0.05). (B) mRNA expression levels of CCL3 in OPM-2 cells (upper panel) and XG-7 cells (lower panel) that were treated or not with 5 µM BIX01294 for 24 hours. Data represent mean ± SD of 3 independent experiments (C) Integrative genomics viewer visualization of H3K9me3 enrichment on EGR2, TRIM69, UB2QL1, and CASP1 genes in XG-7 cells. *P < .05.