Schematic model: control of lineage TF balance by LSD1 defines the metabolic phenotype in EL cells. Overexpressed LSD1 stabilizes GATA1, which activates glycolysis and heme biosynthesis genes while LSD1 suppresses CEBPA expression via H3K4 demethylation. Lineage-specific transcription factors GATA1 and C/EBPα are mutually restraining. Therefore, LSD1 inhibition derepresses CEBPA expression and downregulates GATA1 function, leading to metabolic remodeling and growth arrest.