Individual-level analysis of clinically meaningful improvements for the EORTC QLQ-C30 scales included in the primary analysis for treatment responders vs nonresponders. Global health status/QoL (A), physical functioning (B), fatigue (C), and pain (D). Data are for the EORTC QLQ-C30–evaluable population. Percentages of patients with clinically meaningful improvements were calculated from the total number of patients who provided answers for ≥50% of the items on the given scale. Improvement was defined as a ≥10-point increase from baseline (global health status/QoL and physical functioning) or ≥10-point decrease from baseline (fatigue and pain). Any time point means 1 or more time points from 1 month to 18 months.