Survival implications of clonal hematopoiesis at high age. (A) Kaplan-Meier curve for overall survival (OS), according to the presence of CH. (B) Kaplan-Meier curve for OS stratified according to mutational spectrum: individuals carrying variants exclusively in DNMT3A and/or TET2 (isolated DT) vs all other individuals with CH (others). (C) Forest plot for risk of death, according to the presence of recurrent (>10×) gene mutations. Circles indicate hazard ratios, with lines extending to the 95% CI. (D) Probability of cause-specific death for individuals with and without CH. Results are based on calculations by the authors using nonpublic microdata from Statistics Netherlands. The category of spliceosome variants includes SF3B1, SRSF2, and U2AF1.