Treatment with the WNT inhibitor G007-LK, pyrvinium, or salinomycin prevents leukocyte infiltration in cGVHD-induced dermal fibrosis in the B10.D2 (H-2^d) → BALB/c (H-2^d) model. (A) WNT inhibitors effectively prevented the infiltration of leukocytes, particularly B cells and T cells, in murine skin after allogeneic transplantation without changing regulatory T cells. (B) Treatment with WNT inhibitors reduced Th1 and Th2 cell infiltration in murine skin after allogeneic transplantation. (C) WNT inhibitors reduced total macrophage, M1 macrophage, and M2 macrophage infiltration in allogeneic murine skin. (D) Representative immunofluorescence images of HEp-2 cells incubated with murine serum for ANA detection (original magnification ×200; left panel). Percentages of ANA⁺ mice (n = 6 mice per group; right panel). *P < .5; **P < .05; ***P < .01.