Potential avenues to enrich the arsenal of treatment options for VWD. Examples of potential novel genetic- or protein-based strategies for the management of VWD are highlighted. Some approaches could be used to serve all VWD patients, whereas others will be type specific. AAV, adeno-associated virus; ECs, endothelial cells; ECFCs, endothelial colony forming cells (also referred to as blood outgrowth endothelial cells); ECMO, extracorporal membrane oxygenation; IL-11, interleukin-11; LVAD, left ventricular assist device; TALENs, transcription activator-like effector nucleases; VWs, von Willebrand syndrome. Portions of this figure were created using Biorender.com.