GATA2-deficient HSPCs derived from iPSC can commit to NK lineage differentiation. (A) NK cell output, defined as live CD45⁺CD3⁻CD56⁺ cells, upon 3 weeks of NK-specific differentiation. A minimum of 2 independent experiments were performed (control, n = 6; ZF, n = 8; Int5, n = 6; P = NS by ANOVA). (B) Percent NK output and absolute number of NK cells differentiated from isogenic lines. The experiment was performed once.