Mechanisms of MYC and BCL2 deregulation within molecular subtypes. (A) Mechanisms of MYC deregulation within molecular subtypes. (B) Mechanisms of BCL2 deregulation within molecular subtypes. Tumors are arranged from lowest to highest mRNA expression within each subtype, and mRNA expression levels are shown relative to the full cohort as log₂(Z scores). The vertical dotted black lines indicate the mean expression of MYC or BCL2 within the full cohort. Ticks represent tumors with the indicated SVs, and their proportional distribution within each subtype is represented by curves relative to mRNA expression levels. Ticks on the right side of the vertical dotted black line represent tumors with mRNA expression levels above the cohort mean; ticks on the left represent tumors with mRNA expression levels below the cohort mean. The distributions of IHC-positive and IHC-negative tumors are also shown relative to mRNA expression levels.