ePRO secondary end points: pain, functionality, and fatigue during VOC days. (A) The severity scale included 4 items for worst, least, and average pain in the last 24 hours, and pain right now as reported by the subject, scored 1 (least) to 10 (worst). (B) The functional health status was based on activities of daily living/return to normal activity as recorded in the Return to Normal Activity Questionnaire (RNAQ). It was scored as 1 (cannot do at all) to 10 (can do as usual) and included 4 measures: physical, social, self-care, and daily activities. (C) The fatigue score was scaled from 1 (least fatigue) to 10 (worst fatigue) according to the tiredness Numerical Rating Scale. Pain, fatigue, and RNAQ used an 11-point numerical rating scale. Patient-reported outcomes on non-VOC days were compared with those on VOC days by using a mixed model approach adjusting for baseline. Results are reported as means with 95% confidence intervals. Red bars, non-VOC days; blue bars, all VOC days; green bars, at-home VOC days. *P < .001.